<p>In June 2021, Zimbabwe experienced a third COVID-19 wave characterized by a 3.6% case fatality rate compared to 1.6% in the first wave and 2.6% in the second wave. Sixty-eight percent of these deaths were among hospitalized patients. We investigated the characteristics and outcomes of hospitalized COVID-19 patients at a central hospital in Harare from 2020 to 2022. The findings of the study are critical in informing strategies to reduce morbidity and mortality.</p>