<p>Resistance rates among E. coli and other Gram-negative bacilli were 24.33% and 22.09% among all resistant strains isolated. The risk of resistance among isolated bacteria from 2019 to 2021 was significantly high among species of Acinetobacter, Citrobacter, Enterobacter, E. coli, Neisseria gonorrhoeae and Methicillin Resistant Staphylococcus aureus (PR 1.29,1.29,1.24,1.89,1.38 and 1.23, as compared to proteus species (P&lt;0.05). Antimicrobial resistance prevalence to selected pathogen-antibiotic combinations was significantly high during the COVID-19 pandemic with a rise of 14.5% in 2021, (P&lt;0.05) as compared to 2019. High resistance rates were observed in Cephalosporin’s, Macrolides, Penicillin’s and sulfonamides showing resistance rates of 70.6%,62.2%,83.0% and 78.6% respectively. Age group of 21-59 was at higher risk of developing antimicrobial resistance (36.74%) compared to other age groups (P&lt;0.05).</p>