<p>In conclusion, our study findings showed a relationship between COVID-19 cases and deaths with comorbidities, residence, elderly age (as a proxy for age) and vaccination status. Timely identification of the key evidence-based factors that might mitigate COVID-19 infections and deaths in Rwanda is pertinent for better management of the current and future pandemics. This may include investing in healthcare universal coverage, capacity building and infrastructure, disease surveillance, public health laboratories, and all other aspects that relate to health as elucidated in the WHO International Health Regulations. Specifically, to Covid-19 mortality and associated risk factors, special care should be attributed to elderlies as this study revealed that the risk of death is increased in this group of people. The risk may also be increased in people living with comorbidities, as they are immune suppressed;</p>