<p>Adolescent girls and young women (AGYW) in Zimbabwe are at high risk of acquiring HIV. In 2020, HIV incidence among AGYW was 9.5 times that of males. AGYW are targeted for Pre-Exposure Prophylaxis (PrEP) as part of combination HIV prevention. In Mazowe district, 28.7% of AGYW initiated on PrEP in 2021 self-discontinued within a month of commencement. This reduces PrEP effectiveness and increases risk of emergence of HIV drug resistance. We determined factors associated with PrEP self-discontinuation among AGYW in Mazowe.</p>