<p>South Sudan being in the meningitis belt has experienced meningococcal meningitis outbreaks in 2006, 2007, 2009 and 2013. On 3rd January 2022, Northern Bahr-El-Ghazal (NBEG) State Ministry of Health was notified of an upsurge in suspected meningitis cases in Aweil State Hospital. We investigated to confirm meningitis outbreak, characterize the outbreak, and identify risk factors to inform control and prevention measures.</p>