<p>Diarrhea is the second leading cause of death among children under five years of age worldwide. Rotaviruses are non-enveloped double-stranded RNA (dsRNA) in the family Reoviridae. Kenya adopted the WHO Generic protocol for hospital-based surveillance to estimate the burden of Rotavirus gastroenteritis in children under 5 years of age. Kilifi county referral hospital is one of the sentinel sites. We sought to evaluate the rotavirus surveillance system in Kilifi County Referral Hospital and describe characteristics of cases by the socio-demographic, clinical presentations, and surveillance system attributes.</p>