<p>Results: Out of 157 664 cases, Windhoek district recorded the highest spatial heterogeneity of 51 132 cases (32.4%). Walvis Bay district recorded the highest mean incidence rate of 47 cases per 1 000 populations and the highest relative risk (RR) of 4. Significant peaks were observed during cold months and months of highest population interactions. At 95 % CI, minimum air temperature (Coefficient: 8.00355; P=0.03758), population&gt;35 years (Coefficient: -1.59434; P=0.00069), and Co-morbidities (Coefficient: 1.287212; P=0.00537) increases COVID-19 morbidity and mortality.</p>