<p>Rotavirus acute gastroenteritis is one of major causes of death in infantile age, with approximately 200 000 of children less than 5 years of age die each year due to severe dehydration. In sub-Saharan Africa, the detection rates of rotavirus diarrhea vary widely from country to country. In Central African Republic (CAR), the introduction of the rotavirus vaccine initially planned for 2020 is still not effective to date. The main objective of our study is to assess the burden of rotavirus gastroenteritis and identify rotavirus strains circulating in CAR during 2017-2021, ten years after establishment of the sentinel surveillance of rotavirus gastroenteritis.</p>