<p>Mpox is a zoonotic disease caused by Mpox virus, which is a member of the Orthopoxvirus family and can cause a severe illness that may mimic smallpox and or chickenpox in humans. In Imo State, the first case was recorded in 2018 with death and the 2022 outbreak started on 6th January 2022 with an increasing number of cases. We investigated the magnitude of Mpox outbreak in the state.</p>