<p>Diabetes mellitus (DM) is a serious and a rapidly growing public health burden that affects millions of people. It is estimated that 27-37% of diabetes patients that are receiving care at Jinja Regional Referral Hospital (JRRH) experience diabetes complication like Neuropathy, retinopathy, diabetes foot and ulcers (ref-clinic records), and this could be attributed to non-adherence to drugs. This study determined the prevalence and factors associated with non-adherence to diabetes treatment among adult patients in care at Jinja Regional Referral Hospital, in order to inform interventions aimed at addressing this problem.</p>