<p>Onchocerciasis is among the neglected tropical diseases (NTDs) which remains a serious public health problem in the world. Rapid Epidemiological Mapping of Onchocerciasis (REMO) was conducted in 1999 by the African Program for Onchocerciasis Control which estimated that the disease affected all the 15 counties in Liberia with 1,113,213 populations at risk. Onchocerciasis has it’s a goal of elimination of transmission by 2025. In accordance with WHO guidelines, during the National Onchocerciasis Elimination Expert Committee (NOEEC) meeting in May 2017, it was decided that Liberia conduct an impact assessment using OV 16 to enable the committee to assess the impact of treatment and review progress towards elimination of onchocerciasis. By May 2018, the Ministry of Health conducted an epidemiological impact assessment that provided evidence on the status of transmission of Onchocerciasis in the Southwest Region and to determine the village level sero-prevalence of onchocerciasis in children 5-9 years.</p>