<p>The characteristics of HP and NHP with COVID-19 were modestly different in three COVID-19 waves in Uganda. Overall, W3 cases were somewhat more similar to those in W1 than W2. However, disease appeared to be less severe in W3 and W1 than W2. As the SARS-CoV-2 pandemic continues to evolve, monitoring waves and new variants should remain a priority to inform response.</p>