<p>Corona virus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has infected &gt;700 million people and killed &gt;6 million globally by February 2023. South Sudan instituted COVID-19 surveillance system to rapidly detect suspected cases and tests cases using polymerase chain reaction (PCR) and antigen rapid diagnostic test (Ag-RDT). We described the epidemiology of COVID-19 from the first confirmed case on 5th April 2020 to 30th April 2022 to inform prevention and control efforts.</p>