<p>In October 2021, a cholera epidemic was declared in three regions of Cameroon. On February 18 2022, Vibrio cholerae was isolated from a stool sample in Pitoa Health District (PHD), Nord Region. By 5 June 50% (5/10) of the health areas (HAs) in PHD were affected. Considering the high risk of a cholera outbreak, we investigated to describe the outbreak and identify cholera risk factors.</p>