<p>The COVID-19 pandemic exposed the inadequacies of infection prevention control (IPC) programmes and re-emphasized the need for prioritizing and strengthening IPC. The World Health Organization recommends multimodal strategies as a core component for effective IPC programmes. We assessed the effectiveness of an IPC multimodal intervention programme which aimed at strengthening healthcare worker (HCW) safety and IPC capacity at Primary Health Care facility (PHC) level in Nigeria amidst the COVID-19 pandemic.</p>