<p>The Public Health Emergency Operation Center (PHEOC) acts as a central hub for coordinating the planning, response, and subsequent recovery from public health emergencies effectively. In recent years, emerging and reemerging disease, and the health impact of natural and manmade crisis is among the public health threat globally including in Ethiopia. In order to effectively coordinate these emergencies, strengthening the function of PHEOC is important. Hence, this study assesses the experiences of public health emergency operation center implementation in Ethiopia from 2017-2023 and identifies areas that need improvement to coordinate public health emergency management effectively.</p>