<p>We implemented an IPC multimodal intervention programme in six states in Nigeria in a phased approach between April 2021 and July 2023. Interventions included IPC training, facility upgrades, onsite mentorship, facility monitoring coupled with responsive feedback, and supportive supervision and were implemented in 653 PHCs while 289 PHCs were monitored for comparison (non-intervention). We trained and provided mentorship to 878 HCWs in the intervention PHCs. Using a standardized checklist, facilities were monitored monthly on a range of IPC indicators across five components (i.e., screening/triage, training, hand hygiene, Personal Protective Equipment-PPE availability and use, waste management and environmental cleaning). We computed a composite IPC score from these indicators and compared performance in intervention versus non-intervention PHCs at baseline and end-line.</p>