<p>We conducted a community-based cross-sectional study among 344 randomly sampled adults in the three Asante Akim municipalities to assess the uptake of COVID-19 vaccination. The study was conducted from January – March 2023. A semi-structured questionnaire was used to collect information on the uptake of the COVID-19 vaccines and participant characteristics. The proportion of vaccine uptake was estimated and a logistic regression model used to determine the factors (sociodemographic and community-level factors) that influence the uptake of the vaccine at a 5% significance level</p>