<p>Systematic immunization safety surveillance is essential for ensuring vaccine safety and public trust in immunization programs. The introduction of COVID-19 vaccines in Uganda provides the opportunity to conduct active AESI surveillance to generate robust, standardized vaccine safety data to inform decision-making and contribute to global understanding of the safety profiles of COVID-19 vaccines. As COVID-19 vaccines are mainstreamed into routine vaccnation programs ongoing sentinel site surveillance is well positioned to expand to EASIs after newly introduced vaccines other than COVID 19 Vaccines, covering non-EPI focused populations (adults).</p>