<p>From 2018 to 2022, the Kintampo North Municipality recorded 491,936 uncomplicated suspected cases of malaria. Testing was done for 97.3% (478,445/491,936) of which 40.0% (191,343/478,445) were confirmed positive by microscopy and RDT. The district accounted for 14.7% (491,936/3,346,055) of all uncomplicated suspected malaria cases and 11.4% (191,343/1,679,806) of all positive malaria cases from 2018-2022 in the Bono East Region. OPD Malaria cases per 1,000 population ranged from 229 in 2021 to 460 in 2019 with average suspected monthly uncomplicated malaria were 7,535 (SD ± 2,753 cases). Malaria in children under five accounted for 26.8% (128,408/491,936) of OPD malaria cases with an overall positivity rate of 31.5% (60,366/191,343). IPT1 coverage declined from 97.3% in 2018 to 63.7% in 2022. Positivity rate was 49.7% (5,689/11,437) for all suspected malaria in pregnancy. The epidemic threshold using CUSUM2 was crossed five times within the review period.</p>