<p>We selected two pilot states with an average 6-month COVID-19 retrospective test positivity rate of 3% and 140 facilities with a patients’ flow of ≥100 per week. To create demand, support patients’ referral, and distribute test kits, we engaged 160 and 104 staff in Akwa Ibom and Nasarawa States respectively. Patients with respiratory illness were offered the opportunity to self-test serially within a time interval of 7 days using the Standard Q® self-test kit. We followed those who tested positive on self-testing to determine their result status at second test. We determined the proportions of serial test results against patients’ sociodemographic indices, and the association between patients’ sociodemographic indices and vaccination status.</p>