<p>Measles is a highly contagious vaccine-preventable disease. In 2020, measles caused about 60,700 deaths globally, with almost half of the mortalities reported in sub-Saharan Africa. Measles eradication efforts have focused on vaccination and surveillance initiatives. Assessment of measles surveillance systems is key to achieving milestones towards measles eradication. We described trends and assessed the performance of measles case-based surveillance in the Volta Region of Ghana.</p>