<p>We conducted a descriptive study of preparedness activities in the South Region, Cameroon from February to April 2023. We collected data from activity reports and from the South regional delegation staff involved in MVD preparedness. Preparedness activities were organized into seven key pillars: coordination, epidemiological surveillance, specimen transportation and biologic diagnostic, case management and infection prevention and control, risk communication, emergency supply, continuity of essential care and services.</p>