<p>We conducted a cross sectional descriptive analysis of monthly malaria cases reported by the 13 districts in Masaka Region, from January–December 2022. We abstracted data on age, sex and district of malaria cases from the District Health Information System version 2 (DHIS2). We determined frequencies and proportions of each variable. We developed malaria channels for most affected districts in the region by abstracting malaria cases reported in DHIS2 for the past 5 years.</p>