<p>Introduction: Poliomyelitis is a highly contagious viral disease causing disabling paralysis in children aged 0-15 years. Its eradication is the subject of a global initiative and has resulted in a decline in annual incidence of 350,000 cases with 35,000 deaths in 1988, 74 cases in 2015 and 37 cases in 2016. The objective was to analyze AFP surveillance data from Timbuktu region from January 1, 2019 to December 31, 2021 to provide a detailed description in terms of socio-demographic characteristics, vaccination status, final classification, promptness of notification, and time to send samples to the laboratory.</p>