<p>Crimean-Congo hemorrhagic fever (CCHF) is a viral tick-borne disease with a high mortality rate. It is endemic in many countries including in southern Kazakhstan. The Kyzylorda region reported higher-than-expected cases from March to July 2022 (15 compared to 10 in previous year). The mortality rate was 27%. Identification of additional cases and risk factors were needed to reduce transmission.</p>