<p>Yemen has been certified polio-free by WHO in 2006. Outbreaks of circulating vaccine-derived polioviruses (cVDPVs) pose a threat to the eventual eradication of all polioviruses. In 2021 and 2022, two outbreaks of circulating Vaccine Derived Polio virus cVDPV type 1 (cVDPV1) and cVDPV type 2 (cVDPV2) occurred in the midst of the conflict in Yemen. The objectives of the study were to describe trends in the incidence and epidemiology of Acute Flaccid Paralysis (AFP) cases in Sanaa city over the last ten years from 2012 to 2021.</p>