<p>Pre-exposure prophylaxis (PrEP) reduces risk of HIV acquisition among high-risk persons, including adolescent girls and young women (AGYW). District Health Information System 2 (DHIS2) 2021 data from four PEPFAR-supported PrEP sites in Western Uganda facilities showed poor screening for and uptake of PrEP among eligible AGYW. We conducted a quality improvement (QI) project to improve PrEP screening and uptake among AGYW at these sites during January-June 2022.</p>