<p>Uganda has one of the highest global burden of malaria cases, with over 90% of the population at risk. The disease is responsible for 30 - 50% of outpatient visits and 15 - 20% of hospital admissions. For many years malaria has been the leading cause of outpatient department (OPD) attendance in the Masaka Region. According to the Uganda Malaria Action Program for Districts’ report (MAPD) of 2021, malaria was responsible for 32% of all out-patient (OPD) visits in Masaka Region. We determined the incidence of malaria in Masaka region by person, place and time from January to December 2022.</p>