<p>The resurgence of Mpox has posed a global health threat. In Nigeria, first case was reported in 1971. In December 2017, Nigeria witnessed re-emergence of the disease in some states. The index case in Delta State in 2022 was in a 33-year-old male who lived in Ghana and travelled to Delta State to seek for health care. Following this case, Delta State has experienced sporadic outbreaks reporting 30 confirmed cases and no deaths in 2022. We conducted a descriptive analysis of MPX cases in Delta State.</p>