<p>Background: Zoonosis are diseases transmitted from animal to human that affect more than a billion people with a million deaths a year. Following the devastating war eruption, a cluster of anthrax cases had been notified to the Tigray region health bureau of Ethiopia. In the protracted war and deadly siege of a humanitarian crisis, the magnitude and risk factors of the notified anthrax outbreak remain unknown. The aim of this study was to investigate and give a response to the Anthrax outbreak in Tigray, Northern Ethiopia</p>