<p>From 2017 to 2021, 300 AFP cases were recorded. Majority, 86.3% (259/300) of the cases were investigated within 14 days of onset of paralysis. Non-polio AFP rate ranged from 2.9 to 5.9/100,000 population. Averagely, 88% (265/300) timeliness and 83% (251/300) stool adequacy were achieved compared to WHO target of &gt; 80%. Median age of cases was 3 (range: 1 – 46) years. Majority, 74% (222/300) of the cases were under five years and more than 54% (163/300) were males. Three cases of circulating Vaccine Derived Polio Virus type2 (cVDPV2) was recorded in Sekondi Takoradi, Tarkwa Nsuaem and Jomoro districts in 2020. Vaccination coverage for OPV and IPV were below 90%.</p>