<p>Expound on sample size determination.&nbsp;</p><p>More descriptive data and stratified analysis will help - age of the patients, their level of mobility etc(did they have the ability to move on their own or the decision was dependent on others?), distance from centers, severity of episode, their frequency of attacks.</p><p>You can also share the outcomes of the 224 bleeding episodes. Were there any deaths for example? or hospitalizations? that will emphasize the need to address this issue</p>