Cholera remains a public health threat in Ghana with over 20,000 cases and 243 deaths recorded in the most recent countrywide cholera outbreak in 2014. Before the Covid-19 pandemic, Volta region was noted for its consistent reporting of suspected and confirmed cases. We noticed that there was decline in zero reporting of these cases when Covid-19 was confirmed in the region. We evaluated the cholera trends in Volta Region, prior to, and during the Covid-19 Pandemic to understand the trends in cholera in relation to COVID-19.