Majority (80.9%) of measles cases were unvaccinated against measles. Age of child greater than 5 years [AOR= 0.44, 95% CI (0.24-0.79)], being vaccinated against measles [AOR= 0.16, 95%CI (0.08-0.34)] and receiving 2 or more doses of measles vaccine [AOR 0.16, 95% CI (0.10-0.32)] were independent protective factors for contracting measles. Chimanimani District measles vaccine coverage was 70–89% in 2018 to 2022. VE was 84% (95% CI: 66-92%) in children aged 9-59 months.