Influenza is caused by influenza viruses A, B, C, &amp;amp; D and typically characterized by seasonal epidemics and sporadic pandemics. H1N1 and H3N2, subtypes of Influenza A virus are responsible for seasonal influenza in humans. Globally, over 3 million cases and &amp;gt;290,000 deaths occur yearly. On 27th April, 2022, four OYESS students reported at Assin Foso Polyclinic with Influenza-like illness (ILI) signs &amp;amp; symptoms. Oro/Nasopharyngeal swabs specimens for ILI were picked for RT-PCR testing at Noguchi, Accra. We conducted investigation to establish existence of an outbreak, ascertain the magnitude, characterize the distribution, and measures to prevent further spread.