Nyakabande Transit Centre (NTC) is a temporary shelter for refugees arriving in Kisoro District from the Democratic Republic of Congo (DRC). Due to conflict in DRC, approximately 34,000 persons arrived at NTC between March and June 2022. On June 12, 2022, Kisoro District reported that there had been &amp;gt;330 cases of COVID-19 among NTC residents over the last two months. We investigated this outbreak to assess its magnitude, identify risk factors, and recommend control measures.