Descriptive and 1:2 unmatched case-control study was conducted at Abobo district from September 29–November 19,2021. To confirm cases, 98 nasopharyngeal samples were collected and 29 of them were tested positive by polymerase chain reaction. Cases were any person with onset of ARIs within past 10 days and have at least one of the following; cough, sore throat, shortness of breath or runny-nose.   For case-control part, 62 cases were recruited by computer-generated simple random sampling and 124 controls were selected from neighbors of cases. We used structured questionnaire to collect socio-demographic and determinant factors data from mothers/caregivers. Multivariate logistic regression was fit to identify factors associated RSV infection at p-value of &amp;lt;0.05. 