Of 8,532,992 HIV tests among AGYW 10-24 years, 168,633 (2.0%) were positive. AGYW aged 20-24 had the highest positivity rate (2.6%, 95% CI 2.5-2.6). There was a 5% (OR=0.95, 95% CI 0.94-0.95) reduction in HIV positivity among AGYW 10-24 years from 2.0% in 2017 to 1.7% in 2021. The HIV positivity rate decreased in most districts but remained &amp;gt;3% in the Western Ugandan districts of Mbarara, Sheema, Rwampara, and Kalangala. Among 2,672 newly diagnosed AGYW 15-24 years who received recency testing, 359 (14%) were RTRT-recent. Clusters of recent infections were observed in specific sub-counties in Western Uganda and the central divisions of Kampala Metropolitan.
