In Ghana, 43% of all mortalities are as a result of Chronic Non-Communicable Diseases (CNCDs). Poor adherence to treatment has been shown to influence CNDC morbidity and mortality rates. However, there is a dearth of literature on the psychosocial aspects of treatment adherence in some Ghanaian settings. This study assessed the psychosocial aspects of CNCDs and their impact on treatment adherence in the Ho Municipality.