Literature was retrieved from CINAHL, EMBASE, Google Scholar, PubMed, Scopus, and Web of Science databases. The Joanna Briggs Institute’s critical appraisal tool for prevalence studies were used. A pooled statistical meta-analysis was conducted using STATA Version 17.0. The heterogeneity and publication bias were assessed using the I2 statistics and Egger’s test. The random effect model was used to estimate the summary prevalence and the corresponding 95% confidence interval (CI) of depressive disorder among neoplasm patients. The review protocol has been registered in PROSPERO number CRD42022352778. The PRISMA flow chart was used to show the number of articles identified, included, and excluded with justifications described.