We hypothesized that the outbreak was associated with the consumption of chibwantu. Given the frequent outbreaks linked to homebrews in Zambia — including this one — more thorough laboratory testing of suspected tainted products, including time-of-flight mass spectrometry, is needed to identify potential underlying causes. In the meantime, Zambia should develop health communication messaging that emphasizes safe food practices specific to homebrewing since cessation of this practice is unlikely.