We conducted a mixed-methods cross-sectional study, between January and April 2022, among residents in Hoima district, Uganda. We used multi-stage sampling to survey a random sample of 379 adult participants from 13 systematically sampled villages in two rural sub-counties in Hoima. A participant who was voluntarily willing to receive COVID-19 vaccination was categorized as willing. We also interviewed eight purposively selected key informants who were healthcare workers actively involved in vaccination services. We conducted multivariable-modified Poisson regression analysis to generate prevalence ratios(PR). A thematic approach was used for qualitative data analysis.