A cross-sectional study was conducted among SARS-CoV-2 patients admitted to the Nyarugenge treatment center from June to October 2021. An analysis of death reports was conducted, and a bivariate and multivariate logistic regression was computed to determine the factors most frequently recorded as the cause of death in patients with SARS-CoV-2 infection. Odds ratio (OR), 95% confidence interval (CI), and p-value &amp;lt;0.001 were reported 