Leptospirosis is a zoonotic re-emerging disease caused by the leptospira species. Globally the incidence of leptospirosis is estimated to be 1.03 million cases and 58900 death per year. In Tanzania, the incidence of leptospirosis is estimated to be 75-102 cases per 100,000 persons. On July 5, 2022, an outbreak of an unknown disease characterized by headache, epistaxis, bloody cough, vomiting, fever, and bleeding was reported in Ruangwa Lindi, Tanzania where we had to investigate and identify the etiology of the outbreak of the unknown disease.

