Of the total 48,473 people tested for CD4 count, 4,995 (10.0%) had severe immunodeficiency. The median age of persons with severe immunodeficiency was 39 years (Range: 5– 103 years), and 53% (n=2647) were males. National Reference Laboratory (25%) and Motebang Hospital Laboratory (14%) reported the highest proportion of clients with severe immunodeficiency. Cryptococcal antigen test, a screening test for cryptococcal disease recommended for people with advanced HIV was done for 1723 (34.5%) people with CD4 counts &amp;lt;200 cells/mm³.