The overall prevalence of hypertension increased from 16% in 2016 to 27% in 2021, with a 2.1% annual increase. In 2016, the Central region had the highest prevalence of 18 per 100 OPD cases (OR=1.049 95%C1 1.048-1.050), followed by the western region at 12 per 100 OPD cases (OR=1.126 95%C1 1.125-1.128), 11 per 100 OPD cases in the eastern region (OR=1.037 95%C1 1.035-1.038), and the lowest at 6 per 100 OPD cases in northern region (OR=1.103 95%C1 1.101-1.105). Western region had the highest increase of 3.3% between 2016 and 2021. There was an overall positive trend of hypertension in all regions of Uganda. The trend observed was statistically significant (p= &amp;lt;0.001).