Foodborne outbreaks related to homebrewed beverages, such as the traditional beverage chibwantu, are a significant public health issue in Zambia. Chibwantu is made from fermented grind maize, water, plant roots, and sugar, and is consumed during social gatherings. In January 2023, a birthday party in a village in Southern Province, Zambia, led to 45 individuals developing acute gastrointestinal symptoms, including diarrhea and vomiting. Additionally, a child aged 7 years died after exhibiting additional symptoms of hallucinations, convulsions, and respiratory distress. An outbreak investigation was conducted to determine the cause and scope of the outbreak.