Almost all the HCWs were aware of COVID-19 vaccines (98.7%). Intention to accept the COVID-19 vaccine was high (83. 3%). The reasons for vaccine acceptance were to protect against infection (74.8%), vaccines have been proven to be effective (58.0%) vaccines are safe (46.6%), and vaccines have no side effects (7.9%). Reasons for vaccine hesitancy included vaccine-related concerns such as side effects, concerns about efficacy, rush in the production of the vaccines, and perception/myths. Vaccine acceptability was associated with ethnicity and perception of the COVID-19 vaccine. Yoruba’s were 2.6 times more likely to accept the vaccines [OR 2.6 (95% CI (1.04-6.71)]. Also, respondents who had a poor perception were 0.9 times less likely to accept the vaccines [OR 0.9 (95% CI (0.03-0.20)]. Some HCWs expressed concerns about the content of the vaccine, speed in vaccine development, availability of the vaccines, side effects, and distrust in the government.