Fine particulate matter (PM2.5) is among the air pollutants that pose health risks to humans, with levels &amp;gt;15 µg/m3 being associated with serious health effects. PM2.5 is a measure of air quality associated with such health effects. Cities are more prone to poor air quality compared to non-urban areas. We assessed the spatio-temporal trends of air quality based on PM2.5 concentrations in Kampala City, Uganda.