Result: A total of 23 case-patients and 46 matched controls were enrolled in this study, 16 (69.6%) case patients and 30 (65.2%) controls were Male, The age of case-patients was 21 (91.3%) was over 5 years, and 2 (8.7%) of cases was under five years. According to Sign and symptoms 17 (73.9%) case-patients reported having severe dehydration, All 23 (100%) case-patients was hospitalized and 6 out of 23 case Lab test was performed, and all of six cases were positive, and all Vibrio cholera O1 was identified in their stools. Drinking untreated/unsafe Pond water were (OR 9, 95% confidence interval [CI] 1.85-14.76). Drinking untreated/unsafe Pond water were 9 times more likely to developed AWD/Cholera than those who didn’t drink Drinking untreated/unsafe Pond water.