A descriptive cross-sectional study was conducted among 432 adults living with cancer, diabetes, stroke, hypertension and Chronic Kidney Disease attending various chronic disease clinics in the Ho Teaching Hospital. A structured questionnaire, adapted from the DASS 21, MSPSS, EQ-5D-5L and MARS protocols, was used to collect data on psychological distress, perceived social support (PSS), health-related quality of life (HRQoL) and treatment (medication, lifestyle/behavioural treatment (diet, sleep, exercise, rest), and review attendance) adherence levels from respondents. Descriptive and inferential statistics were done, with odds ratios generated at 95% CI.