As of February 2022, over 56,900 cases resulting in 1,400 deaths had been confirmed in Ghana. Due to the novelty of COVID-19, little is known about the epidemiology of the disease in the Ghanaian context. With increasing morbidity and mortality, it is important to conduct a study to determine the distribution of disease in the population. We therefore established the incidence and distribution of COVID-19 in Ayawaso West Municipality in the Greater Accra Region to inform policy direction.