Hepatitis B Virus (HBV) is a vaccine-preventable condition with an increased risk of death from complications such as cirrhosis and liver cancer. The World Health Organization estimated 296 million people with HBV, an incidence of 1.5 million yearly. In 2019, 820 000 related deaths from liver cancer were reported globally. This study was conducted to assess the quality of HBV surveillance data and to estimate the prevalence of HBV in Mpumalanga Province.