A qualitative study was conducted in the city of Maputo and the capitals of Maputo, Gaza, Inhambane, Manica, and Zambezia Provinces in the first quarter of 2022. Men who have sex with men, people who inject drugs, female sex workers, transgender people, and pimps, previously contacted by community-based organizations, police, and health professionals, participate in individual and focal group interviews, conducted with standardized scripts on risk behaviours and access to health and support services since the first state of emergency for COVID-19 in March 2020. Data collection continued until saturation of responses was reached. Analysis was based on grounded theory principles.