: We conducted unmatched case-control study from February 25, 2021 to April 14, 2021 in Kurmuk woreda. Stool samples were sent to National Polio and Measles laboratory at Ethiopian Public Health Institute confirmation of Rotavirus in cases.  Structured questionnaire was developed to collect cases and controls. A total of 144 samples with 1:2 cases to controls were selected. Data were analyzed using Epi-Info and the results were interpreted using Adjusted Odds ratio, P value &amp;lt;0.05 and 95% CI. 