We analyzed malaria surveillance data from 2016-2021 from the District Health Information System (DHIS2) for the IRS-receiving districts of Serere, Pallisa, Kibuku, and Budaka. We compared the average monthly malaria incidence three months before and after IRS during 2016-2020 with incidence three months before and after IRS in 2021. We conducted focus group discussions and key informant interviews with district teams involved in IRS to assess chemical transportation, storage, mixing, training, spraying, and quality control.