The case fatality rate of rabies in Tigray increased alarmingly during the prolonged war and deadly siege, while the rabies notification rate was low due to the systematic communications blackout. Qualitative results indicate that almost all rabies prevention and control measures, including the One-Health approach, have been discontinued. Therefore, the Tigray bureau of health and agriculture to revitalize the rabies surveillance system, and partners are expected to compel the federal government to open the siege and avail supplies for dog bite victims like PEP.