On May 18, 2021, there were 3,405,682 fatalities and 164,305,625 coronavirus cases worldwide. A total of 4,738,237 coronavirus cases with 126,913 fatalities had been reported throughout Africa. There were 4,008 fatalities and 266,646 confirmed COVID-19 cases in Ethiopia. The first verified COVID-19 case in Ethiopia was discovered on March 13, 2020. There were 38 fatalities and a total of 6188 COVID-19 confirmed cases in the Tigray region as of October 19, 2020.  The objective of the study was to identify the magnitude and risk factors of death in Covid-19 patients among the treatment centers of admitted patients in the Tigray region of Ethiopia in 2020