Five main themes emerged from our analysis: vaccine calculation, confidence, complacency, convenience, and collective responsibility for vaccine determinants. We found that the students had vaccine hesitancy because of the vaccine calculation as explored by misinformation and myths as regards the COVID-19 vaccine. Another germane determinant of vaccine hesitancy was vaccine confidence: we found that trust in the safety, effectiveness, the system that produces the vaccine, and in the policymakers affected the vaccine uptake. Also, vaccine convenience was another determinant as the factors explored availability, accessibility, and introduction of fees can cause vaccine hesitancy.