Globally, estimated neonatal tetanus deaths decreased by 85%, from 170,829 in 2000 to 25,000 in 2018. Neonatal mortality among babies in Ghana also increased from 53% to 71% between 1990 and 2014. Ghana saw 291 cases and 179 fatalities, with the Central Region accounting for 6.9% of cases and 3.4% deaths. We conducted a descriptive analysis of the NNT surveillance system to inform interventions and enhance neonatal surveillance. 