The study showed that 14.8% of TB-HIV co-infected patients died during the study period. Of these, 85% of deaths occurred in the two first months of TB treatment. Predictors of mortality were no nutritional support (aOR=1.97, 95% CI: 1.3–2.99), body mass index &amp;lt;18.5 (aOR=1.83, 95% CI: 1.36–2.48), being TB clinically diagnosed (aOR=1.52, 95% CI: 1.03–2.23), not started ART (aOR=14.51, 95% CI: 9.13–23.06), not being followed by Community Health Worker (aOR: 3.73, 95% CI: 2.4–5.81), the patients treated in Referral Hospitals (aOR= 2.0, 95% CI: 1.35–2.97) and those treated in District Hospitals (aOR=2.61, 95% CI: 1.67– 4.08).