We conducted a cross-sectional study in two districts in the Gauteng Province. We defined a case as confirmed when toxigenic Vibrio cholerae O1 or O139 was isolated from patients presenting with watery diarrhoea using a polymerase chain reaction and/or stool culture test. A structured in-person interview was conducted to gather demographic and clinical characteristics. Stool and rectal samples were collected for laboratory testing and serotyping. Water samples were taken for laboratory analysis. We used descriptive statistics to summarise the data.