We employed an unmatched case-control study (1:1 ratio) A case was any person residing in Kenema City and presenting with generalized body weakness, vomiting, or nausea from July 25 to 31, 2022. A control was any person residing in Kenema City at the specified time without symptoms suggestive of food poisoning. We interviewed respondents and reviewed clinical records to collect demographics, clinical, exposure, and epidemiological variables. Food and environmental samples were collected for bacteriological and toxicological testing.  We calculated attack rates for each food item and adjusted Odds Ratio (aOR) with a 95% confidence interval (CI) to assess factors independently associated with food poisoning. 