A total of 1418 pertussis cases were reported from fifteen districts in saadah governorate, of them one case died (CFR: 0.1%). The peak of cases occurred in September 2021. Two-thirds (69.5%) were &amp;lt; five years and (52.2%) were females and only 43% develop apnea. Based on the vaccination status, and (87%) were unvaccinated and only (2%) received three doses. The overall IR was 11.6/10000 of the population, significantly higher among &amp;lt; 5 years’ cases (86 vs 4, p&amp;lt; 0.001). Furthermore, four districts that were difficult to access (Al Hashwah, Haydan, Majz, Al safra) had higher IR compared to the others (18 vs 7, p&amp;lt; 0.001).