From 2018 to 2021 in Andijan Province, 1,098 people were newly diagnosed with HIV, of which 113 (10.3%) did not initiate ART. Participants were mostly 30-49 years old (49%), male (56%), married (46%), and with secondary education (74%). Also, 39% and 31% had HIV clinical stage I and II, respectively. Risk for non-initiation was higher among people with secondary education (RR=8.6; CI=1.2–60.9]) compared to higher education, with multiple partners (RR=2.7; CI=1.5-5.0]), with disease stage I (RR=3.3; CI=2.0–5.2]) and stage II (RR=4.4; CI=2.8–7.0]). People with sexual partners living with HIV had higher risk of non-initiation (RR=1.8; CI=1.2–2.9]) than people with partners that did not have HIV. Being single was associated with reduced risk of non-initiation (RR=0.1; CI=0.03–0.3]).