A retrospective cross-sectional study was conducted among 1954 TB-HIV co-infected patients from all health facilities in Rwanda. They were registered in the national individual case-based surveillance system (e-TB) from July 2019 to June 2021. Data were extracted from e-TB and analyzed using Stata Version 16.0. Bivariate and multivariable logistic regressions were performed to determine factors associated with mortality. 