About 4 million people are said to be affected by the disease worldwide and it is deemed a serious public health problem in at least 10 African countries. Eleven million Ethiopians (18% of the population) are at risk through exposure to the irritant soil and it is estimated that at least 1 million people are affected. Therefore, this study aimed to identify determinants of Podoconiosis in Machakel woreda, East Gojjam zone, Amhara, Northwest Ethiopia, 2022.