Since 2010, Zambia has implemented influenza-like-illness (ILI) and severe acute respiratory infections (SARI) sentinel surveillance to monitor influenza. During the COVID-19 pandemic, patients with ILI/SARI were also tested for SARS-CoV-2. We investigated prevalence of SARS-CoV-2 infection in the ILI/SARI sentinel surveillance system in Zambia.