A prospective multi-center observational cohort study was conducted among PLHIV in Ghana from August 2020 to September 2022. We recruited newly diagnosed and known HIV-positive patients being initiated on DTG based regimen and followed each up for 18-months. Normal CRP levels was defined as less than 0.3mg/dl. Person-time and incidence rate (IR) were estimated using “stptime” function in STATA. Cox proportional hazard model with robust standard error was employed.