Nkhata Bay district had the highest number of cholera cases, 577 (28.2%) followed by Blantyre, 541 (26.4%) and then Nsanje, 290 (14.2%). Lilongwe, Mangochi and Mwanza had the lowest number of cases with one case each (&amp;lt;0.001%). AR was high in Nkhata Bay (189), Nsanje (90), Neno (85), Nkhotakota (50) and Blantyre (40). Case fatality rate, CFR, was higher in men (3.7%) than in females (3.2%). The highest number of cases (130) was registered in a single day was on August 16, 2022. The age of cases ranged from 9 months to 90 years with a mean of 26 years. The highest number of cases were in the age groups: 0 to 5 years (13.9%) and 21 to 25 (14.8%). Majority of cases were men, 1143 (55.9%) with women representing 903 (44.1%) cases. Possible risks factors included: drinking from unsafe water sources, poor personal hygiene and not using sanitary facilities