Zambia continues to experience the threat of poliovirus, with wild-type and vaccine-derived outbreaks. Thus, ensuring high-quality acute flaccid paralysis (AFP) surveillance is critical to detecting any cases of paralytic polio. However, Southern province has not met the national target of detecting at least 2 non-polio AFP (NP-AFP) cases per 100,000 children &amp;lt;15 years. We did an AFP surveillance system evaluation in Southern province to make recommendations for improvement. 