Adopting a community-based cluster design, we collected data from a representative sample of 861 respondents in 30 enumeration areas of Ilorin metropolis selected proportionally to their estimated population. We used a questionnaire adapted from the 7C vaccination readiness scale. We reported descriptive statistics using frequency and percentages for categorical variables; mean and standard deviations for continuous variables. We used the chi-square test to evaluate associations between dependent and independent variables and conducted multivariate logistic regression to predict acceptance of a COVID-19 vaccine at a P-value of &amp;lt; 0.05.