We searched for cases across the 27 local government areas (LGAs) in the state using the adopted standard case definition for Mpox as person with acute illness with fever &amp;gt;38.3 °C, intense headache, lymphadenopathy, back pain, and rashes progressing all over the body including soles of feet and palm of the hands. We collected sociodemographic and clinical data and generated a line list. We collected swabs and blood samples for laboratory confirmation using reverse transcription polymerase chain reaction (RT-PCR). We calculated rates and proportions.