We conducted a cross-sectional survey among 420 students from four randomly selected senior high schools in the Jasikan Municipality. We administered a structured questionnaire on socio-demographic factors, attitudes and perceived barriers towards COVID-19 and its vaccination, adverse events following immunization (AEFI), previous COVID-19 infection, adherence to COVID-19 protocols, and constructs of the health belief model. Data were analyzed using descriptive and inferential statistics. Multivariate logistic regression was performed to identify the determinants of vaccination uptake, with a significance level set at p&amp;lt;0.05.