Out of the 475 study subjects, 51.4% (244) of the respondents had adequate knowledge on COVID-19 prevention and control and 58% had positive attitude and perception.  The multivariable analysis results indicated that HCWs working in referral (Adjusted Odds Ratio= 0.4 95% Confidence Interval: 0.18-0.76) and general hospitals (AOR= 0.4 95% CI: 0.21-0.84) had 60% lower odds of inadequate knowledge compared to those working in health centers. Similarly, being male (AOR= 0.4; 95% CI 0.27-0.65), nurse (AOR= 7.9; 95% CI 1.47-42.25), midwife (AOR= 6.7; 95% CI 1.97-38.19) and pharmacist (AOR=15.9; 95% CI:  2.89-87.30) were significantly associated with inadequate knowledge. Likewise, males and midwives had 50% and 70% lower odds of negative attitude and perception, respectively. 