We identified the number of weeks malaria cases exceeded the threshold (‘epidemic weeks’) using the three methods for all weeks in 2022 in six districts. Thresholds were calculated using historical data from the health management information system (HMIS) 033b weekly reports (2017-2021). We evaluated Alebtong, Nwoya, and Moroto districts (high malaria transmission with &amp;gt;80% reporting rates) and Kisoro, Kanungu, and Rukiga districts (low malaria transmission with &amp;gt;80% reporting rates). All districts currently use the 75th percentile method for epidemic detection.