We identified, 72,114 cases, leading to an overall incidence of 168/100,000 population. Males (195/100,000 population) were more affected than the female (141/100,000 population); persons aged ≥20 years (308/100,000 population) were most affected. Karamoja region (373/100,000 population) was the most affected followed by Kampala (252/100,000 population) and West Nile (239/100,000 population) with the least being Teso (111/100,000 population) and Bukedi (94/100,000 population). The months with high peaks of new confirmed TB cases included March (9/100,000 population), June (9/100,000 population), and September (13/100,000 population). This coincided with months (March and September) where the CAST TB campaign is conducted on an annual basis. 