 In the past five years (2017–2021), Plasmodium falciparum (P. falciparum) was the predominant species; accounting for 55.7%, and 44.3% was Plasmodium vivax (P.vivax). The proportion of malaria cases was higher among males (54%) than females (46%). Higher malaria cases were observed in the age group &amp;gt;15 years (63.9%), followed by the age group of 5–14 (22.1%), and 14% were under five years of age. Yeki district accounted for 47.6% (13,318/27,975) of malaria cases, followed by Tepi town with 28.6% (7994/27/975) cases. Malaria cases declined from 4710 in 2017 to 3162 in 2020 and then increased to 12212 in 2021. 