 Retrospective follow-up study was conducted among 746 children enrolled in anti-TB treatment from 2012 to 2021 in the Awi zone. The data was collected from the patient’s TB treatment follow-up card, and TB registers book using a data extraction checklist. Epi Data (v-4.6.0.0) was used for data entry and exported to STATA (v-14) for cleaning and statistical analyses. Life-table and Kaplan–Meier survival curves were used for estimating the median survival time and cumulative survival probability of unfavorable TB treatment outcomes. Predictors of time to unfavorable TB treatment outcome among children were examined by bi-variable and multivariable Cox regression. The proportional hazard assumption was checked both graphically and statistically. The results were reported as an adjusted hazard ratio with 95% CI at a significance level of p&amp;lt; 0.05 (two-sided test).