A Community based unmatched case-control study with a 1:1case to control ratio was conducted in the Siraro District from 16 June 2022 to 03 August 2022. Seventy-four randomly selected cases and controls participated in this study. We reviewed the previous five year’s malaria data to establish a threshold level. Both descriptive and analytical statistical procedures were performed. The data were entered using Epi -Info version 7.2.4.0 software and analyzed by using SPSS version 25. Multivariable logistic regression analysis was conducted to identify independent factors associated with malaria infection.