Globally, an estimated 200,000 cases of Yellow Fever (YF) are recorded yearly. YF is endemic in Ghana and is associated with severe disease in approximately 15% of cases with a high case fatality.  Periodic analysis of surveillance data is key to evaluate the impact of interventions needed to develop strategies to prevent future outbreaks. We described the epidemiological characteristic of yellow fever cases from 2017 to 2021 to inform interventions in the Upper East Region of Ghana.