The National Malaria Control Programme (NMCP) usually conducts a mass distribution campaign of insecticide-treated mosquito nets every three years. From the 15th to the 17th of November 2021, the NMCP distributed 428,514 nets to 166, 564 households in Chikwawa district. The impact of the mass net distribution on malaria incidence at the district level has not been documented yet. This analysis sought to evaluate the incidence of malaria before and after mass net distribution