Overall, the region reported 809,670 cases with an incidence of 312 cases/1,000 population from January–December 2022. Females were more affected (342 cases/1,000) compared to males (280 cases/1,000 population). Cases aged 10-19 years were most affected with an incidence of 406 cases/1,000 population while cases aged 20 years and above were least affected with an incidence of 228 cases/1,000 population. Rakai District was the most affected with 542 cases/1,000 population while Masaka District registered lowest incidence of 159 cases/1,000 population. The malaria channels indicated an upsurge in the region in most parts of the year 2022.