Recommended vaccination at nine months of age with measles-containing vaccine (MCV1) has been part of Ethiopia’s immunization program since 1980. A second-dose of MCV (MCV2) was introduced in February 2019 for children 15 months old. Oromia Region is the most populous region and contributes close to half of the unvaccinated children in the country. In 2021, we examined MCV1 and MCV2 coverage and factors associated with measles vaccination status.