<p>Out of 2700 patients recruited, 73.4% were female. Participants mean age was 46.5 ± 11.8 years. Estimated total person-months of DTG exposure was 28152 with overall incidence rate (IR) of high CRP levels being 23.7 (95% CI: 21.9-25.5) per 1000 person-months. CRP levels IR at 3, 6 &amp; 12 months were 171.4 (95% CI: 150.1-195.8), 117.9 (95% CI: 107-130) and 66.1 (95% CI: 60.9-71.8) per 1000 person-months respectively. The IR of CRP among males 23.2 (95% CI: 20.0 – 26.9) per 1000 person-months was similar to that of females 23.8 (95% CI: 21.8 – 26.0) per 1000 person-months. The IR of CRP among ART naive patients 34.8 (95% CI: 26.7 – 45.3) was higher compared to that among those previously on ART 23.0 (95% CI: 21.2-24.9). Presence of comorbid conditions was associated with 2.35 (95% CI: 1.1-1.3) times higher risk of developing high CRP levels.</p>