<p>This study employed a quasi-experimental study. We conducted a single group before and after study. First, we conducted a baseline survey so as to assess the students’ awareness, knowledge and practices about blood donation. We then shared IEC materials (videos, fact sheets) on the different aspects of blood donation with the students and thereafter conducted an endline survey to assess the change in students’ awareness, knowledge and practices about blood donation. The study was conducted in four schools in Eastern Uganda (i.e. two schools in Jinja and two schools in Mayuge districts). The two study districts were purposively selected i.e. Jinja to represent an urban district and Mayuge to represent a rural district. We worked with the district education officers to purposively select two secondary schools within in each district. By the time we conducted the baseline survey, only S.3, S.4, S.5 and S.6 students were present at the school. We included only S.3 and S.4 students for the baseline survey. By the time of we conducted the endline, the students had been promoted to the next class and therefore we included S.5 and S.6 students in the endline so as to maintain the same study population. For both the baseline and endline survey, census sampling was used to recruit the students. At each schools, we called for an assembly were we informed the students about the study. All the interested students were given self-administered questionnaires. Consent forms were attached to questionnaire.</p>