<p>Among 7,092 participants, 4,717 (66.5%) consented to blood draw and 4,642 (65.5%) consented to nasopharyngeal swab. Overall SARS-CoV-2 positivity was 9.4% by PCR and 3.8% by ELISA. SARS-CoV-2 prevalence was higher among PLHIV by PCR (12.4% vs 9.1%, OR: 1.4, 95% CI: 1.0-1.9) and lower by ELISA (1.9% vs 3.9%, OR: 0.5, 95% CI: 0.2-0.9). Among PLHIV, not being on ART was an independent predictor of SARS-CoV-2 test positivity (aOR: 7.4, 95% CI: 1.5-37.9). PLHIV had higher odds of symptomatic SARS-CoV-2 infection (OR: 2.3, 95% CI: 1.3-4.2).</p>