<p>This study found high HIV viral non-suppression among children and adolescents in Tabora, and was associated with poor ART adherence level, low CD4 count, NVP, EFV and LPV/r based regimen, and switching to a second-line regimen. Intensified comprehensive efforts are required to improve viral suppression rates and attain the 3rd goal of the UNAIDS 95-95-95.</p>