<p>We performed a cross-sectional descriptive study. Laboratory-confirmed enteric fever cases identified nationally between 2020 and 2022 were interviewed telephonically or face-to-face using a standardized case investigation form. Whole-genome sequencing was performed on isolates and investigated using multiple bioinformatics tools. Drinking water samples were collected from the North West Province, tested and analysed. Descriptive analysis was performed using Microsoft Excel.</p>