<p>The proportion of malaria cases that were severe consistently declined from 2017-2021, suggesting progress in the control and management of uncomplicated cases. However, some regions are still experiencing increases. The burden in treatment of severe malaria cases appears to be shifting from lower-level health facilities to regional referral hospitals. Additional efforts to improve management of uncomplicated malaria in Bukedi and North Central regions and strengthening case management generally could reduce severe malaria in Uganda.</p>