<p>Out of 537 isolates with 15 pathogenic bacteria, 478 (89%) were from blood, 34 (6.3%) from pleural fluid, 21(4%) from cerebrospinal fluid, and 4 (0.7%) from peritoneal fluid. The most common pathogen was Staphylococcus aureus (20.1%), followed by Salmonella species (18.8%). Overall change in resistance over the four years was 63–84% for sulphonamides, for cephalosporins 8.3–90%, fluoroquinolones macrolides 46–76%, phenicols 48–71%, penicillins 42–97%, β-lactamase inhibitors 20–92%, and aminoglycosides 17–53%. It was lower for carbapenems 5.3-26%, and glycopeptides 0–20%. Annual resistance rates to ciprofloxacin increased significantly from 2018-2021 for Gram-positive organisms (26-45% p=0.02) while Gram-negative organisms, there were increases in resistance to tetracycline (29-78% p&lt;0.001), ciprofloxacin (17-43%, p=0.004), ceftriaxone (8-72%, p=0.003), imipenem (6-26%, p=0.004), and meropenem (7-18, p=0.03).</p>