<p>We conducted a 1:1 unmatched case- control study in Chimanimani District. A case was a person residing in Chimanimani District who developed signs and symptoms of measles or tested IgM positive from 06 August to 06 September 2022. Controls were neighborhoods who did not have measles signs and symptoms. Cases were randomly selected. We recruited 126 cases and 126 controls. An Interviewer-administered questionnaire, line list, records of cases and key informant interviews were used to obtain information about the outbreak. We estimated vaccine effectiveness (VE). We conducted bivariate and multivariable logistic regression.</p>