<p>A total of 173 single clinical isolates with median age 27(1-76) years were analysed. ESBL-PE frequency was 35 (28.46%) among the 123 Enterobacteriaceae isolates identified. Majority of the ESBL isolates were from gynae ward, 14(40%) followed by surgical ward, 11(31.43%). E. coli was dominant 21(60%) followed by Klebsiella pneumonia 10(28.57%). High resistance rate was observed against Cephalosporins [(Ceftazidime 34(97.14%), Cefotaxime 29(93.55%), Ceftriaxone 33(94.29%)], Cotrimoxazole 33(94.29%) and Gentamycin 32(91.43%). Low resistance rate of ESBL-producers against Nitrofurantoin 8(36.36%) was observed. However, all the ESBL isolates were sensitive to Imipenem antibiotic. Multi-drug resistant isolates were more prevalent among the ESBLs producers 33(94.29%) than non-producers 2 (5.71%) (p = &lt; 0.0001)</p>