<p>We analyzed data from three concurrent SARS-CoV-2 prevalence surveys (household, outpatient-department, and health-worker) conducted in six districts of Zambia in July-2020, during the upswing of Zambia’s first COVID-19 wave. Information on demographics and medical history was collected. Nasopharyngeal swabs were used to screen for SARS-CoV-2 RNA using polymerase-chain-reaction (PCR). Blood samples were screened for SARS-CoV-2 virus-specific antibodies using an enzyme-linked-immunosorbent-assay (ELISA). Test-specific SARS-CoV-2 prevalence was calculated. Multilevel logistic regression models were used to measure adjusted odd ratios (aORs) controlling for location, survey type and demographics and 95% confidence intervals (CIs) of SARS-CoV-2 by HIV status.</p>