We conducted a cross sectional analysis of data extracted from patients clinical records , with a sample size of 800 Female sex workers  enrolled in PrEP service and constituted our dataset for analysis . PrEP uptake is defined as the proportion of potentially eligible people enrolled in HIV pre-exposure prophylaxis service and accepted to be initiated oral pre-exposure prophylaxis. We collected socio –demographic, clinical features  and HIV exposure information. We summarized data in form of frequency and percentages for categorical variable then bivariate and multi-variate analysis using logistic regression to determine factors associated independently associated with the outcome. We report adjusted odds ratios (aORs), 95% confidence interval and P. Value.