<p>Confirmed Rotavirus outbreak was occurred in Kurmuk Woreda with AR of 14.9/1000 and CFR of 0.54%. In multivariate logistic regression, contact with cases (AOR: 4.45, 95% CI: 1.253-16.093, P: 0.021) and respondents who did not know about rotavirus {AOR; 5.6, 95% CI (1.359-19.802) P-value 0.016} were risk factors, whereas fully vaccination {AOR: 0.127, 95% CI (0.043-0.380), P: Value: 0.000}, having latrine {AOR: 0.180, 95% CI: (0.057-0.562), P-Value: 0.003}, and practicing hand washing at least three critical times {AOR: 0.324, CI: (0.106-0.987), P-Value: 0.047} were found to be protective factors.</p>