<p>Blood stock outs are a frequent occurrence in Uganda. Unfortunately for the patients, it is a matter of life and death if they cannot access the much-needed blood. Research shows that knowledge about blood donation remains low in the populace (Checkley et al., 2019). Moreover the inadequate funding of UBTS continues to undermine efforts to generate adequate supplies because it lacks resources for public sensitization. Blood is needed for pregnant women, sicklers, cancer patients, surgical procedures and road traffic accidents. Approximately 55.8% transfusions go to female patients and 33.2% to children under five years (Checkley et al., 2019). In the past Uganda has relied on international partners and the corporate sector to boost its supply but this support still falls short of set targets. Moreover donated blood can only be kept for 35 days and plateletes last 5 days. Uganda blood transfusion services must therefore replenish its stock frequently. More Ugandans need to become regular blood donors. Many UBTS blood donation drives are conducted in secondary schools. However, not much has been done in raising awareness about blood donation in schools. We developed and tested high impact communication strategies to increase awareness about blood donation among secondary school students in Uganda inorder to increase knowledge and awareness of blood donation so as to increase the willingness and intention to donate blood among secondary school students.</p>