<p>COVID-19 vaccine reduces COVID-19-associated morbidity and mortality. Uganda began COVID-19 vaccination in March 2021 and has used a variety of vaccines, including AstraZeneca, Johnson &amp; Johnson, Moderna, Pfizer, Sinopharm and Sinovac. The WHO Global strategy on COVID-19 vaccination targeted national coverage of 10% by September 2021, 40% by December 2021 and 70% by June 2022. We assessed COVID-19 vaccination uptake and coverage in Uganda during March 2021 through June 2022 to evaluate progress towards targets and identify gaps for evidence-based recommendations.</p>