<p>During a ten-year period, 593 cases of AFP were reported in Sana’a city, none of these cases was confirmed as poliomyelitis. 60% was younger than five years of age, and 56% was males. The annual incidence of non-polio AFP ranged from 2.6/100,000 to 4.9/100,000 (Mean: 3.5 /100,000) which met WHO target. Regarding sample adequacy, all districts met WHO target (&gt;80%) except AL Tahreer district (77%). The most predominant clinical feature was fever (79%). Nearly one third of cases ended with residual paralysis after 60 days follow up (26%). The most common cause of paralysis (27%) was Guillain-Barre syndrome.</p>