<p>The effectiveness of a vaccination program depends on optimal vaccine uptake, even for high-efficacy vaccines. Despite the full-scale implementation of COVID-19 vaccination exercise in the three Asante Akim municipalities, less than 50% of the adult population have received the vaccines. In an attempt to increase coverage, it is important to understand the various factors that affect the uptake. This study assessed the factors associated with the uptake of COVID-19 vaccines in the adult population of the Asante Akim municipalities of the Ashanti Region.</p>