<p>Results: Five cases were detected (incidence: 12/100,000 persons/month), three passively. Plasmodium falciparum was responsible for all five cases, 1(20%) was complicated, 3(60%) were seen as outpatients, 4(80%) were indigenous, all (100%) were Batswana. 3(60%) were males, median age was 20 years (range: 11 – 42 years). Three cases were from Selebi-Phikwe, two from Mmadinare. All case-patients did not sleep under a mosquito net, 3(60%) reported travel outside their place of residence. No case-patient received blood transfusion prior to illness. 2(40%) reported their houses were treated during the previous indoor residual spray (IRS) season in Mmadinare. IRS is not done in Selebi-Phikwe village. Mosquito breeding sites were documented around the residence of all case-patients.</p>