<p>A cross-sectional study was used to assess antibiotic susceptibility patterns, trends and associated factors of clinical bacterial isolates among 8368 samples from 1380 patients. Resistance comparisons between Pre and COVID-19 were made. Antibacterial resistance trends from all specimens and Pathogen- antibiotic combinations in 2019 were used as baseline data and cut-off points of antibacterial resistance percentages, time series analysis assessed the trend for 2020 and 2021. Modified poison analysis assessed factors associated with AMR.</p>