Measles is a highly contagious viral disease and one of the major causes of childhood morbidity and mortality in humanitarian emergencies. South Sudan is experiencing a protracted humanitarian crisis leaving communities vulnerable to multiple outbreaks due to the disruption of health services. Measles vaccination coverage rate in the country remained low at 69% in 2021. Starting in January 2022, the country experienced an increase in measles cases, with outbreaks declared on 23rd February 2022 in Torit and Maban counties in Eastern Equatoria and Upper Nile States respectively, and on the 10th December 2022 countrywide. We described the epidemiological characteristics of the outbreak.