During January-July 2022, a total of 333 case-patients were identified of which 170 (51%) were males, and 178 (53%) aged &amp;lt;5 years.  Out of 76 (23%) CSF specimens collected, 6(9%) were PCR-positive for three pathogens: Neisseria meningitides (2), Streptococcus (2) pneumoniae, and Haemophilus influenzae type b (2). Four of the five counties in NBEG surpassed alert threshold of 3 cases/100,000 people per week, but none reached the epidemic threshold (10/100,000).  Aweil West County had the highest AR (48/100,000 people) compared to overall state AR of 25/100,000 people. Of the 333 case-patients, 31 died (CFR=9%). The CFR was highest in Aweil East County 13% (13/100) and amongst children &amp;lt;1 year 48.4% (15/31).  