<p>Typhoid fever is among the leading causes of morbidity in Low-and-middle-income countries. In Ghana, typhoid fever is endemic with 209/100,000 cases being reported in 2019. The East Mamprusi district recorded increase in typhoid fever cases and outbreaks with case fatality rate of 3.06% in 2019 and 2021. We determined the prevalence of typhoid fever in the district and characterized cases by person, place, and time.</p>