Anthrax is a highly contagious zoonotic disease caused by Bacillus anthracis. Following an increase in the number of patients presenting with skin lesions at Kuajok Hospital between February and March 2022; on 2 April 2022 Gogrial West County (GWC) surveillance unit carried out an investigation and collected skin lesion swabs from 18 patients. On 11 April 2022, eight samples were confirmed positive for Bacillus anthracis by polymerase chain reaction (PCR) leading to declaration of human anthrax outbreak. We investigated to characterize the outbreak, determine the magnitude, and identified exposures to guide control and prevention measures.  