<p>A total of 1,127 suspected and 63 confirmed cases of Lassa fever with 40 deaths (CFR-63%) were reported. Of the confirmed cases, the median age was 26 years (range: 1 to 90 years); females accounted for 57% (36), and most of the cases, 40% (25/63), were between 1-9 years. “The average number of confirmed cases reported per year was 13, with the lowest, 8 cases reported in 2020 and the highest, 16 reported in 2021. The average incidence rate was 2 per 100,000 population. Kenema district accounted for 81% (51/63), followed by Tonkolili and Bo Districts with 10% (6/63) and 5% (3/63) respectively. The peak of infection was in 2021 with 25% (16/63) cases.</p>