<p>A mixed research design involving focused group discussions (FGD), interviews and key informant interviews was conducted among travelers in Ethio-Djibouti border from July 10-30, 2022. The quantitative data were collected from 422 randomly selected participants while qualitative data from four FGDs and eight key informants. Additionally, 342 larvae’s were collected from the discarded tires, water reservoirs and irrigational canals for entomological investigation. The quantitative data were entered in to Epi-data 3.1 and analyzed with SPSS 25.0. The binary logistic regression model was applied to identify factors associated with malaria prevention practice and the strength of association was measured with AOR at p-value &lt;0.05. The qualitative data were analyzed manually and thematically using the content analysis theory.</p>