Dracunculiasis (Guinea worm), a parasitic disease caused by Dracunculus medinensis, is targeted for eradication, globally. In South Sudan, the last reported confirmed case was in 2007. On August 5, 2022, Lafon County surveillance unit received an alert of a suspected dracunculiasis case at Lafon Primary Health Care Centre (PHCC). We investigated to confirm the diagnosis, identify exposures and implement prevention and control measures.