<p><strong>Methods:</strong> A comparative cross-sectional study was with multistage random sampling technique was used to select the study participants among rural and urban slums households. A survey with the integration of the spectrum of skin-neglected tropical diseases, trachoma, and soil-transmitted helminthiases among 580 randomly selected children and their caregiver was conducted. Examinations for skin-neglected tropical diseases, grading of clinical trachoma and microscopic parasitological investigation of soil-transmitted helminthiases using a single Kato-Katz concentration technique were preformed. Structured questionnaires was used to collect sociology-demographic, behavioral and environmental data related to neglected tropical diseases. Standard clinical checklist adopted from WHO guideline was also utilized to undertake clinical examination of selected study subjects to screen for any potential NTDs. Data entered using Epi-Data version 3.1 and analyzed using STATA 16. Descriptive statistics such as frequencies, proportions means were calculated and the differences between groups were assessed using Chi-squared test. The bi-variate and multivariable logistic regression analysis was used to identify the risk factors and the level for statistical significance was declared at p-value &lt; 0.05 with 95 % CI.</p>