<p>&nbsp;Healthcare providers’ adherence to malaria case management guideline was 47.3%; 95% CI: 41%-52% in overall, 50.9%; 95% CI: 41%-58% in public and 43.7%; 95% CI: 36%-51% in private health facilities, respectively. Public health facility (AOR=3.9; 95% CI: 1.7-9.3) in overall analysis were significant factor for adherence to malaria guideline. Bachelor of Science in Nurse (AOR=3.7; 95% CI: 1.13-12.00), health centers (AOR=3.7;95%CI:1.5-9.2), training (AOR=3.4; 95% CI: 1.5-7.4), guideline availability (AOR=3.4; 95% CI: 1.04-11)and supervision (AOR=3.8; 95% CI: 1.6-8.7) were factors associated with guideline adherence in public health facilities while experience &lt;2 years (AOR=3.7; 95% CI: 1.4-9.2), training (AOR=2.37; 95% CI: 1.12-5), job aides displayed(AOR=2.7; 95% CI: 1.24-6.2) and supervision (AOR=3.5; 95% CI: 1.2-9.6) were factors associated with guideline adherence in private health facilities.&nbsp;</p>