<p>An unmatched case-control study was conducted among 264 (88 cases and 176 controls) from April 20 to May 20/2023 of primary school students in Irgacheffe town. Cases were those with typical signs and symptoms of scabies and fulfilled standard criteria, and controls were those free from signs and symptoms of scabies during the study period. Skin examination of scabies was done by trained health professionals. An interviewer-administered questionnaire was used to collect the data. Data were entered into Epi-data version 3.1 and analysed using SPSS-20. Binary logistic regression was used to identify risk factors associated with a scabies infestation. In bi-variable analysis, covariates with p-values (&lt;.25) were selected and included in the multivariable logistic regression. The final model is interpreted using an adjusted odds ratio (AOR) with a 95% confidence interval and p-value &lt;0.05.&nbsp;</p><p><br></p>