<p>The human immunodeficiency virus<strong> </strong>(HIV) case surveillance (CS) system systematically and continuously collects available socio-demographic and health event data of a person with HIV infection from diagnosis until death. Although system evaluation must be conducted regularly to ensure the system works as planned, the HIV CS system evaluation was not performed in Mekelle City. Hence, this evaluation aims to describe the implementation status of the system, describe the attributes, describe the knowledge of healthcare providers, and describe the core and supportive functions of the system.</p>