<p><strong>Background:</strong>&nbsp; Dengue virus and Chikungunya virus are emerging arboviral disease and becoming the major public health threat in tropical and sub-tropical regions of the world. Arboviral diseases, particularly dengue fever and chikungunya outbreaks are frequently reported in the eastern regions of Ethiopia. However, the actual burden and contributing factors are not well studied in these areas. Thus, this study aimed to assess Dengue fever and chikungunya: prevalence, hematological parameters and associated factors among febrile patients in Dire Dawa City Administration, Ethiopia.</p>