<p><strong>Methods: </strong>&nbsp;An unmatched case-control study was conducted in Metema district from March 15 to May 9, 2024, involving 86 measles cases and 172 controls. Cases were individuals with positive serum IgM antibodies or epidemiologically linked to confirmed patients, while controls were asymptomatic individuals from the same neighborhoods. Data were collected using a CDC-adapted structured questionnaire, entered into EpiData 3.1, and analyzed with STATA version 17. Binary logistic regression was fitted to identify factors, with statistical significance determined at p &lt; 0.05 using adjusted odds ratios (AOR) with 95% confidence intervals (CI).&nbsp;</p>