<p>Mpox (formerly known as monkeypox) is a disease caused by infection with a virus, known as <em>Monkeypox virus</em>. This virus is part of the same family as the virus that causes smallpox. People with mpox often get a rash, along with other symptoms. The rash will go through several stages, including scabs, before healing. The first human case of mpox was recorded in 1970, in what is now the Democratic Republic of the Congo. In 2022, mpox spread around the world. Before that, cases of mpox in other places were rare and usually linked to travel or to animals being imported from regions where mpox is endemic. The objective is to review the status of current Mpox Outbreak public Awareness, Health Emergency Preparedness and Response Readiness of Ethiopia to gridlock the expansion of the pandemic.&nbsp; About 46% of participants confirmed they are unaware of its symptoms and transmission mechanisms. Nevertheless our reconnaissance survey result shows that public awareness is at its infant stage on the viral infection, transmission mechanism and preventive treatment systems &nbsp; among citizens of the country. The timely focus and urgency of Ethiopia at critical borders with particular emphasis on checkpoints along three Ethiopian regions, namely Oromia, Somali, and South Ethiopia is the right move to control its emergency in the country.</p>