<p><strong>Results: </strong>In this study, 264 (62.26%, 95%CI: 58% - 67%) of female secondary school students had received HPV vaccine. Urban residence (AOR = 4.71, 95%CI: 1.86 - 11.95), choosing natural science stream (AOR = 2.95, 95%CI: 1.86 - 11.95), mother’s had secondary education and above (AOR = 3.60, 95%CI: 1.09 - 12.01), having good knowledge (AOR =3.14, 95%CI: 1.24 - 6.98) and positive attitude (AOR = 3.83, 95%CI: 1.62 - 9.05) were factors significantly associated with HPV vaccine uptake.</p>