<p>The high levels of antibiotic resistance observed among the commonly prescribed antibiotics are alarming. The emerging resistance to ciprofloxacin and nalidixic acid signals a severe public health threat in the management of shigellosis. The study identified high discrepancy drug resistance between phenotype and genotype and varied in phylogenetic relationships with global isolates. Raising awareness about resistance and educating health professionals, policymakers and the public can help improve patient care quality and rational antibiotic use.&nbsp;</p>