<p><strong>Background:</strong> Measles, caused by the paramyxovirus, remains a highly contagious, vaccine-preventable disease responsible for approximately 2.6 million deaths annually. Despite concerted global efforts by the WHO and UNICEF, measles outbreaks persist in some regions. WHO’s 2009 policy recommended the introduction of a second dose of measles vaccine (MCV2) once the first dose (MCV1) coverage reached 80% for three consecutive years. Ethiopia introduced MCV2 in 2019, but data from 2022 show inconsistent coverage, with the African region at 45% and Ethiopia at 81.72%. This study aims to assess MCV2 coverage and identify factors influencing vaccination rates in Durame town, Kambata zone, to help inform strategies to reduce measles-related morbidity and mortality.</p>