<p><strong>Background:</strong> Despite the determination to succeed in eliminating neglected tropical diseases, it has been shown that there is re-emergence of these diseases within certain endemicities, particularly in depriving regions including Ethiopia. However, study on the burden of most of these diseases and its health-related quality of life in Ethiopia, particularly in the current study area is in its infancy and not well done.This study aimed to assess the relative burden of neglected tropical diseases in rural and urban slum settings in Eastern Ethiopia.&nbsp;</p>