<p>The most prevalent form of leishmaniasis in developing nations is cutaneous leishmaniasis. Leishmaniasis is a serious health issue with a wide range of clinical signs, epidemiological diversity, and a spectrum of aggression. Globally, up to 1.5 million cases are recorded annually, and over 350 million individuals are at risk of cutaneous leishmaniasis. With over 250 cases documented in 2023 alone, Gamo Zone is among the locations with a high incidence of this disease that did not get the due attention. This study aimed to assess the determinants of cutaneous leishmaniasis in Deramalo and Dita districts of Gamo Zone, South Ethiopia.&nbsp;</p>