<p>&nbsp;</p><p><strong>Methods</strong>: Following the descriptive study, a case-control study was conducted in Adigrat town from December 23, 2023 to March 30, 2024. Cases were people who presented with fever and maculopapular or laboratory-conﬁrmed cases or epidemiologically linked with the confirmed person, and controls were neighbors to a case with no signs and symptoms of rubella. Cases and controls were selected using simple random sampling and closest neighbor respectively. Data was collected using a semi-structured questionnaire and analyzed using SPSS version 27. Bivariate and multivariable logistic regression was employed to determine the association of illness with risk factors and tested using the Odds ratio, and 95% confidence interval.&nbsp;</p>