<p>&nbsp;</p><p><strong>Background</strong>: Diabetes mellitus is a growing public health concern globally, with the greatest increase in low and middle-income countries like Ethiopia. It is one of the four leading causes of noncommunicable disease-related morbidity and mortality in Ethiopia. However, there is limited information on the burden of diabetes mellitus, particularly, in the Tigray region. Therefore, this study aims to assess trends and describe the distribution of diabetes mellitus in the Tigray region from 2012-2018.&nbsp;</p>