<p>Among the 534 stool-cultured specimens, 47 (8.8%) were positive for <em>Shigella</em> species. More than 50 % of the isolates were resistant to three and above antibiotics while none of them was susceptible to all antibiotics tested. All <em>S. sonnei</em> isolates in our investigation contained genes encoding <em>blaEC-8 </em>and<em> blaZEG-1</em>. The study also identified genes that conferred resistance to trimethoprim (<em>dfrA</em>). All isolates were sensitive to norfloxacin and 60.7% of the isolates were phenotypically sensitive to cefoxitin among the <em>blaEC-8</em> genes detected in the genotyping analysis, whereas all isolates were completely resistant to amoxicillin and erythromycin phenotypically. Nine serological <em>S. flexneri</em> were <em>E. coliO37:H10</em> and the phenotypic and genotypic AMR data corresponded well for amoxicillin and ampicillin only, across susceptibility profiles. Extended-spectrum beta-lactamase (ESBL) <em>blaEC-15</em> for cephalosporins, <em>blaMIX-2</em>, and <em>blaMIX-6</em> for penicillins were detected in <em>E. coliO37:H10</em>. The most common plasmid type in <em>E. coliO37:H10 </em>isolates unlike <em>S. sonnei</em> was <em>IncFII</em> and virulence genes such as <em>gad</em> were frequently detected.&nbsp;</p>