<p><strong>Result:&nbsp;</strong>A total of 642 HIV-infected adults were followed for 1571.9 person-years of observation (PYO). Out of 642, 117 (18.22%) died with an overall mortality rate of 7.44 per 100PYO (95% CI: 6.21–8.92 per 100 PYO). The incidence rate of death in TB/HIV co-infected and TB-free patients was 10.92 per 100 PYO and 4.26 per 100 PYO, respectively. The effect of TB on mortality was 2.56 (95% CI: 1.72–3.82). Age<span style="text-decoration: underline;">&gt;</span>45years (AHR=4.08, 95%CI: 2.21–7.50), bedridden (AHR =2.26, 95% CI: 1.06–4.81), WHO stage IV (AHR= 2.8, 95% CI: 1.0–7.15),&nbsp; anemia (AHR = 3.1, 95%CI: 1.74–5.54), OI (AHR = 2.71; 95%CI:1.03–7.13),&nbsp; CPT use(AHR = 0.51, 95% CI: 0.28–0.91) and poor adherence (AHR=3.83,95%CI: 1.58–9.28) were significant risk factors of mortality.&nbsp;</p>