<p><strong>Method:</strong> A hospital-based retrospective cohort study was conducted among HIV-infected adults on ART with TB and without TB from January 1, 2018, to December 30, 2022, at Awi Zone public hospitals. Computer-generated simple random sampling was used to select 642 adults. Then, 321 TB/HIV co-infected and 321 TB-free PWH were recruited and followed for the occurrence of death. The Cox proportional hazard assumptions were not satisfied. Weibull regression was the best-fitted model after being selected by Akaike information criterion. An adjusted hazard ratio (AHR) with a 95% CI at P-value &lt; 0.05 was used to declare significant predictors of mortality.</p>