<p>&nbsp;| Globally, healthcare workers (HCWs) are at the frontline of Coronavirus Disease 19 (COVID-19) pandemic prevention and response measures. However, fear and hesitation due to the occupational risk coupled with knowledge gaps can compromise the COVID-19 prevention and control measures. Therefore, this study was conducted to assess the knowledge, perception and attitude of HCWs towards COVID-19 prevention and control in Tigray, Ethiopia, to fill the gap in evidence.&nbsp;</p>